Lab Members

Current lab members

Dr Simon Johnston

I did my PhD with Professor Laura Machesky on the Arp2/3 complex and the actin cytoskeleton, and was a post-doc with Professor Robin May working on host pathogen interactions of Cryptococcus. Now I am occasionally allowed in the lab to do microscopy.

James Bradford (Hawkins lab)

I completed a Masters degree in Physics and Astrophysics in 2016, where I became interested in using simulations to understand physical systems. I'm currently a fourth year PhD student supervised by Rhoda Hawkins in Physics. My project involves the computational modelling of phagocytosis, to help understand the role of actin in force generation.


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Jaime Cañedo

I finished my Bachelor's degree in University of the Philippines Baguio and my Master's degree in Cardiff University, where I worked in the lab of Prof. Helen White-Cooper, using optical imaging and mathematical analysis to investigate the transport of a unique set of intracellular proteins in Drosopila spermatids. Currently, I'm a third year PhD student, specialising on phagocyte biology and biophysics. My project aims to understand the mechanical events during particle uptake by the immune cells. To explore this, we use different types of live imaging, super-resolution and electron microscopy techniques combined with Monte Carlo simulation experiments. We work very closely with theoretical physicists to understand this complex biophysical process in immune cells.

Outside the lab, I enjoy singing with my choir, travelling and exploring the beautiful sceneries of the UK and Europe.


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Jacob Rudman

I completed Masters in Pharmacology at the University of Bath in 2017. Here, I found a passion for studying respiratory disease, further solidified by a year-long industrial placement at GSK in the respiratory department.

Now I am a third year DiMeN DTP (MRC) PhD student, who is attempting to understand how the healthy immune system is able to clear Cryptococcus neoformans in the lung. To do this, I use mouse models and ex vivo precision cut lung slices to directly visualise host-pathogen interactions in mammalian tissue.

In my spare time, I maintain a live music review blog, take part in tough mudders and am currently designing combat robots.


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Chris Donaldson

I'm a 3rd year PhD researcher, having joined the lab in 2017 after completing BSc Pharmacology and MSc Translational Neuroscience . My research, funded under an MRC DiMeN DTP studentship, is focused on developing therapies for cryptococcal meningitis. For this, I have developed and optimised zebrafish models for high-throughput drug screening. In addition, I have been researching how antifungals get in to the central nervous system, and how this can be modulated for improved disease outcomes.

When I'm not in the lab, I'm usually busy with my many, many plants, trying to build something or working on disability equality in academia.


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Stella Christou

I finished my undergraduate degree at the University of Aberdeen with a BSc (Hons) in Microbiology in 2017.

Currently I am a third year PhD student supervised by Professor Kathryn Ayscough (BMS) and Dr Simon Johnston. My studentship is funded by BBSRC DTP White Rose. I work on elucidating the role of cell wall composition and hyphal switch during the host-pathogen interactions of a commensal fungal pathogen called Candida albicans.


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Jacqui Chalakova

In 2018 I completed a Master’s degree in Translational neuroscience. During my masters project I was supervised by Prof. Marysia Placzek. I contributed to her work in understanding the genetics of early hypothalamic development in the chick embryo animal model. During my master's degree I found a passion for incorporating different scientific disciplines to understand neurological pathologies, which lead me to my choice of an interdisciplinary project for my PhD.

My PhD project works on the understanding of the mechanisms of raised intracranial pressure in cryptococcal meningitis. My focus is the pathophysiological processes arising from the biophysical properties of the pathogen. It appears that cryptococcal infections affects intracranial pressure in a very complex way, involving all the components of the cranium: brain, vasculature and CSF circulation. My project involves using a zebrafish infection model to mimic the mechanisms that cause this increase in pressure.


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Arturo Landeros de la Isla (Sayers lab)

I studied my undergrad in biotechnology engineering at the National Polytechnic Institute in Mexico. After that I applied for a direct PhD at the IICD department of the Medical School. My work is focused on DNA replication inhibitor as potential antimicrobial agents against parasitic (Trypanosoma brucei and Leishmania infantum) and fungal organisms (Cryptococcus neoformans).

I really love my country and my culture and I will constantly speak about (specially food, which sometimes I cook if you want to give it a try).


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Mahrukh Shameem

I joined the lab in 2019, as part of the DiMeN DTP. Having completed a MSc in Clinical microbiology and having work in Dr Catherine Pashley’s Clinical mycology lab, I developed a strong interest in opportunistic infections in respiratory disorders. My project - in collaboration with AstraZeneca – aims to observe the effects of the IL-33/ST2 pathway in chronic respiratory diseases and infections. We will use an inter-disciplinary approach to explore this field.

Throughout this PhD I also hope to promote inclusivity within academia and STEM by representing women and the black and minority ethnic (BAME) community.



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Previous lab members

Dan Jones


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Louise Richards

Dr. Aleksandra Bojarczuk


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Dr. Katherine Pline


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Dr. Harriet Knafler

Dr. Hamid Fehri


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Dr. Josie Gibson


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Dr. Robbie Evans


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Dr. Alfred Kamuyango


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